Lidocatine and fentanyl are frequently used as analgesic agents or blockers of pain pathway. To evaluate the influence of lidocaine and/or fentanyl to nerve conduction, we divided 29 wistar rats (200~300 gm) into four groups such as 4% lidocaine
(2
mg/100g) dripping, mixed solution (4% lidocaine and fentanyl) dripping. fentanyl (dripping, fentanyl (2.5 ug/100g) dripping, saline solution dripping. Rats were anesthetized with ether and pentothal sodium (2 mg/100g) and their sciatic nerves
were
surgically exposed and were dripped with experimental solution according to groups. Sensory nerve action potentials (SNAP) were examined according to time sequence such as pre-dripping, post-dripping 2 min., 5 min., 10min., 20 min., 30 min.,
respectively.
@ES The results were as follows:
@EN 1) Significantly prolonged latencies and decreased amplitudes were noted in 2 min., 5 min., 10 min. and 20 min. after dripping of lidocaine as compared to that of pre-dripping, respectively (P<0.05).
2) Significantly prolonged latencies were noted in 2 min., 5min., 10min., 20 min., and significantly decreased amplitudes were noted in 5 min. and 10 min. after dripping of mixed solution as compared to that of pre-dripping, respectively
(P<0.05).
3) There was no significant change between pre- and post-dripping of fentanyl or saline solution, respectively (p>0.05).
So we concluded that lidocaine or mixed solution (lidocaine and fentanyl) was effective in blocking of nerve conduction, but synergic effects of fentanyl addition was not observed in nerve conduction study.
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